Ethacrynic acid
Edecrin, Ethacrynic Acid (ethacrynic acid) is a small molecule pharmaceutical. Ethacrynic acid was first approved as Edecrin on 1982-01-01. It is used to treat ascites, chronic kidney failure, edema, heart failure, and hypertension amongst others in the USA.
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Commercial
Trade Name
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Edecrin, Ethacrynic acid (discontinued: Edecrin, Ethacrynic acid)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ethacrynic acid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EDECRIN | Bausch Health Companies | N-016092 RX | 1982-01-01 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| edecrin | New Drug Application | 2015-12-10 |
| edecrin sodium edecrin | New Drug Application | 2020-08-31 |
| ethacrynate sodium | ANDA | 2022-11-14 |
| ethacrynic acid | ANDA | 2024-02-23 |
| ethacrynic acid ethacrynic sodium | NDA authorized generic | 2023-08-31 |
| ethacrynic sodium | NDA authorized generic | 2015-07-01 |
Indications
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Agency Specific
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HCPCS
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Iron overload | D019190 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | — | — | — | — | 1 |
| Non-muscle invasive bladder neoplasms | D000093284 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ethacrynic acid |
| INN | etacrynic acid |
| Description | Etacrynic acid is an aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor. It has a role as an ion transport inhibitor, an EC 2.5.1.18 (glutathione transferase) inhibitor and a loop diuretic. It is an aromatic ether, a monocarboxylic acid, an aromatic ketone and a dichlorobenzene. It is functionally related to an acetic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(CC)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 58-54-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL456 |
| ChEBI ID | 4876 |
| PubChem CID | 3278 |
| DrugBank | DB00903 |
| UNII ID | M5DP350VZV (ChemIDplus, GSRS) |
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Estimated US medical usage
Ethacrynic acid
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Trends
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Safety
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Adverse Events
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183 adverse events reported
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